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VALCHLOR^® (mechlorethamine) gel is a prescription medicine used on the skin (topical) to treat people with Stage IA and IB mycosis fungoides–type cutaneous T-cell lymphoma (MF-CTCL) who have received previous skin treatment. It is not known if VALCHLOR is safe and effective in children.

Understanding MF-CTCL

What is MF-CTCL?

MF-CTCL, which stands for mycosis–fungoides type cutaneous T-cell lymphoma, is the most common cutaneous T-cell lymphoma (CTCL). The disease is typically slow growing and may be mistaken for other inflammatory skin conditions such as eczema or psoriasis, which VALCHLOR does not treat. MF-CTCL may be present for years or even decades before it's diagnosed.

Getting a CLEAR picture of Stage IA/IB MF-CTCL

You are not alone. Stage IA/IB MF-CTCL is thought to affect 16,000 to 20,000 patients in the United States. MF-CTCL is a progressive disease with distinct stages, each of which has a different treatment approach.

Although MF-CTCL can occur anywhere on your body, it often appears on skin that is covered by clothing and unexposed to sunlight.

Symptoms of MF-CTCL: what it may look like

Your stage of MF-CTCL is based on how much of your body has red patches of skin and/or scaly raised scabs called plaques.

Artistic rendition of Stage IA/IB MF-CTCL as Patches

Stage IA/Patch

Artistic rendition of Stage IA/IB MF-CTCL as Plaques

Stage IB/Plaque

Artistic rendition of Stage IA/IB MF-CTCL as Hypopigmentation

Stage IA/IB/Hypopigmentation

Actual patient examples.

Stage IA: patches and/or plaques cover up to 10% of the skin

Stage IB: patches and/or plaques cover 10% to 79% of the skin

Most patients have Stage IA/IB MF-CTCL for several years
In some cases, it can progress to later-stage disease

Getting started with VALCHLOR

Download patient education brochure
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Explore VALCHLOR Support^®

Important Safety Information

VALCHLOR gel is for use on skin only. Do not get VALCHLOR near or in your eyes, mouth, or nose as it can cause pain, redness, swelling, burning, and ulcers. It can also cause sensitivity to light, blurred vision, and may also cause blindness or permanent eye injury. If VALCHLOR gets in your eyes, rinse your eyes right away for at least 15 minutes with a large amount of water, normal saline, or an eyewash solution. If it gets in your nose or mouth, rinse the affected area right away for at least 15 minutes with a large amount of water. Get medical help right away.

Do not use VALCHLOR if you are severely allergic to mechlorethamine. Tell your healthcare provider if you have had an allergic reaction to mechlorethamine.

Before using VALCHLOR, tell your healthcare provider about all your medical conditions including if you are pregnant, planning a pregnancy, or breastfeeding:

Avoid becoming pregnant during treatment with VALCHLOR. VALCHLOR may harm your unborn baby.
Females who are able to become pregnant, and males with female partners who are able to become pregnant, should use a barrier method of birth control such as a male condom or spermicide during treatment with VALCHLOR.
It is not known if VALCHLOR passes into breast milk. Do not breastfeed during treatment with VALCHLOR.

VALCHLOR is flammable. Avoid fire, flame, and smoking until VALCHLOR has dried.

Serious Side Effects Include:

Risk of secondary exposure to VALCHLOR for caregivers who accidentally come into contact with VALCHLOR may include risk of skin inflammation (dermatitis); injury to eyes, mouth, or nose; and certain types of cancer. If accidental contact occurs, thoroughly wash the affected area with soap and water right away for at least 15 minutes and remove any contaminated clothing. Get medical help right away if VALCHLOR gets in your eyes, mouth, or nose.
Skin inflammation (dermatitis) is common with VALCHLOR and may sometimes be severe. Risk for dermatitis is increased if VALCHLOR is applied to your face, genital area, anus, or skin folds. Tell your healthcare provider if you develop skin reactions such as redness, swelling, itching, blisters, ulcers, and skin infections.
Increased risk of certain types of skin cancers. Certain types of skin cancer can develop on treated and non-treated areas with VALCHLOR. Your healthcare provider will check your skin for skin cancers during and after treatment. Tell your healthcare provider if you get any new skin lesions.
Most common side effects include redness, swelling, itching, skin ulcers or blisters, skin infection, and darkening of areas of your skin.
VALCHLOR may cause fertility problems in females and males. This could affect the ability to become pregnant. Talk to your healthcare provider if this is a concern for you.
These are not all of the possible side effects of VALCHLOR. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Keep VALCHLOR and all medicines out of the reach of children.

Applying VALCHLOR

When applying VALCHLOR, caregivers must wear disposable nitrile gloves, which should be safely thrown away in the household trash. Wash hands with soap and water after touching or applying VALCHLOR. Apply right away or within 30 minutes once taken out of the refrigerator. Refrigerate VALCHLOR right after each use. Apply a thin layer to completely dry skin at least 4 hours before or 30 minutes after showering or washing. Let treated area dry for 5 to 10 minutes after applying VALCHLOR before covering with clothing. Moisturizers may be applied to the treated areas 2 hours before or 2 hours after applying VALCHLOR. Do not use airtight or watertight bandages on areas treated with VALCHLOR.

Please see the full Prescribing Information and Medication Guide (EN/ES). for VALCHLOR.